Georgia Institute of Technology researchers were part of a three-continent,
multi-organizational effort known as “Operation Jupiter” that successfully
identified and shut down manufacturers who were flooding Southeast Asia with
counterfeit – and ineffective – anti-malarial drugs.
With 11 different organizations, including the Centers for Disease Control
and Prevention (CDC), the World Health Organization (WHO), the Wellcome Trust –
and ultimately the international law enforcement agency INTERPOL – the global
effort provided Chinese officials with enough information to shut down the drug
makers.
Beyond the human health cost of failing to effectively treat hundreds of
thousands of malaria cases, the fake drugs could be fueling development of
malarial strains that may become resistant to the most sophisticated drug now
available to treat the disease: artesunate. That’s because counterfeiters
sometimes include small quantities of the real drug in their fakes, possibly as
part of an effort to fool simple quality tests. By not killing the malaria
parasites, the small amount could facilitate development of drug resistance.
As their part of the investigation, Georgia Tech researchers used sensitive
mass spectrometry techniques to analyze nearly 400 drug samples provided by
public health authorities. They also developed methods to speed up analysis,
including an ionization process that reduced the time required to test a drug
sample from half an hour to just a few seconds.
Full story.